Cell kinetic modelling and the chemotherapy of cancer by Helmut Knolle

Cover of: Cell kinetic modelling and the chemotherapy of cancer | Helmut Knolle

Published by Springer-Verlag in Berlin, New York .

Written in English

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Subjects:

  • Cancer -- Chemotherapy -- Mathematical models.,
  • Cancer cells -- Growth -- Mathematical models.,
  • Cytokinesis -- Mathematical models.,
  • Cell Cycle.,
  • Models, Biological.,
  • Neoplasms -- drug therapy.

Edition Notes

Includes bibliographical references (p. [151]-155) and index.

Book details

StatementHelmut Knolle.
SeriesLecture notes in biomathematics ;, 75
Classifications
LC ClassificationsRC271.C5 K64 1988
The Physical Object
Paginationviii, 157 p. :
Number of Pages157
ID Numbers
Open LibraryOL2047585M
ISBN 103540501533, 0387501533
LC Control Number88024812

Download Cell kinetic modelling and the chemotherapy of cancer

During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. neforedrug testing on animal tumors was directed to observation of the incfease in life span of.

Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy.

When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor. Cell kinetic modelling and the chemotherapy of cancer.

Berlin ; New York: Springer-Verlag, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Helmut Knolle. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy.

When clinical oncologists began to apply cell kinetic concepts in practice about 15 years Cell kinetic modelling and the chemotherapy of cancer book, the theoretical basis was still very poor, Cited by: Cell Kinetic Modelling and the Chemotherapy of Cancer by Helmut Knolle,available at Book Depository with free delivery worldwide.

Get this from a library. Cell Kinetic Modelling and the Chemotherapy of Cancer. [Helmut Knolle] -- This monograph establishes a necessary link between experimental cancer research and mathematical modelling of cell population and presents a new approach to the old problem of building a rational.

Indeed, cell kinetics are a corner-stone of many theoretical concepts in the treatment of cancer by radiation or cytotoxic drugs (Frei et al. Skipper and PerrySkipperClarksonKlein and LennartzSouthwest Oncology GroupWithersValeriote and EdelsteinGereckeSwanSmets ).Cited by: 1.

Booktopia - Buy Chemotherapy books online from Australia's leading online bookstore. Discount Chemotherapy books and flat rate shipping of $ per online book order. The proposed tumor-volume kinetic model.

In this section, we summarized the proposed model used in this study. A detailed description of the derivation of the equations and biologicl assumptions are given in the following sections.

Two cell types, or two-components, in the tumor, dividing cells, and non-dividing cells, were included in the by: The purpose of this book is to show how mathematics can be applied to improve cancer chemotherapy.

Unfortunately, most drugs used in treating cancer kill both normal and abnormal cells. However, more cancer cells than normal cells can be destroyed by the drug because tumor cells usually exhibit different growth kinetics than normal cells.

PDF | The dynamic of cancer is intimately linked to a dysregulation of the cell cycle and signalling pathways. It has been argued that selectivity of | Find, read and cite all the research you. Anesthesia Student Survival Guide: A Case-Based Approach - Ebook written by Jesse M.

Ehrenfeld, Richard D. Urman, Scott Segal. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Anesthesia Student Survival Guide: A Case-Based Approach. The ability of the model to predict tumour response induced by chemotherapy, based on CA values, was assessed.

Results: Data from ROC patients were used to model CA kinetics and tumour. Author(s): Knolle,Helmut Title(s): Cell kinetic modelling and the chemotherapy of cancer/ Helmut Knolle. Country of Publication: Germany Publisher: Berlin ; New York: Springer-Verlag, c Good illustrations and an up-to-date survey of essential literature makes it rather easy for the reader to become familiar with additional references.

Thus, the book can be recommended to specialists and to students interested in this promising field. Kunze, Gatersleben Knolle, H.: Cell Kinetic Modelling and the Chemotherapy of Cancer.

where N∞ is the plateau cell number which is reached at large values of r and the parameter b is related to the initial tumor growth rate. This is the same equation recast (taken from Wikipedia.)where K is the carrying capacity, i.e.

the maximum size that can be reached with the available nutrients, and α is a constant related to how fast the cancer cells multiply. We build a multicompartment model for cancer chemotherapy following preceding modeling attempts.Because the cell cycle comprises four phases (mitosis, Gap 1, synthesis and Gap 2) and cells can also be found in a quiescent status (Gap 0), the most general model must consider five different compartments representing the cell populations in each of them (see Fig.

1(a)).Author: Álvaro G. López, Kelly C. Iarosz, Antonio M. Batista, Jesús M. Seoane, Ricardo L. Viana, Miguel A.F. Biomathematics and cell kinetics - PDF Free Download. Cancer is a leading cause of death worldwide. Many management options exist for cancer with chemotherapy and surgery being the most widely used.

The ultimate goal of all therapies is to eradicate/ control cancer while keeping toxicity at low levels. Mathematical models describing the mechanisms underlying cancer can be used as aFile Size: KB. Introduction. This paper presents a novel extension of a non-linear drug kinetic model, by Evans et al., on the in vitro uptake of the anti-cancer agent topotecan (TPT) for live human breast cancer cells (MCF-7 cell line) in order to account for cell transporters and drug resistance proteins.

In this paper, the transporter located in the cell membrane acts as an efflux pump to drive the Cited by: 4. The function f is the growth rate of the malignant dividing cell and depends on both the total volume of actively dividing cells, V T, and the tumor vascular volume, V function g is the transition rate of the dividing cells to the non-dividing cells under the influence of radiation.

Both f and g are a function of dose second term in Equation indicates that the non-dividing dead Cited by: Cell cycle effects of drugs are concentration dependent. In collaboration with Michael M. Gottesman, Stein demonstrated that high and low concentrations of cytotoxic chemotherapy can provoke two entirely different effects on cell cycle events in NIH3T3 cells despite their intact cell cycle check points: reversible G2/M versus irreversible G1 and S arrest.

From the mathematical kinetic, and stochastic game theory to modelling mutations, onset, progression and immune competition of cancer cells. Physics of Life Reviews, 5 (), No. 4, – Physics of Life Reviews, 5 (), No. 4, –Cited by: () Studying cancer-cell populations by programmable models of networks.

Network Modeling Analysis in Health Informatics and Bioinformatics() Multispecies model of cell lineages and feedback control in solid by:   In this work we review past articles that have mathematically studied cancer heterogeneity and the impact of this heterogeneity on the structure of optimal therapy.

We look at past works on modeling how heterogeneous tumors respond to radiotherapy, and take a particularly close look at how the optimal radiotherapy schedule is modified by the presence of by: 3.

Triple-negative breast cancer (TNBC) is cancer that tested as negative for estrogen receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor receptor 2 (HER2) protein which accounts for 15%–20% of all breast cancer cases.

TNBC is considered to be a poorer prognosis than other types of breast cancer, mainly because it involves more aggressive phenotypes that are Cited by: 9. Neoadjuvant chemoradiation (NCRT) followed by total mesorectal excision is the standard treatment for locally advanced rectal cancer (LARC).

To justify a non-surgical approach, identification of pathologic complete response (pCR) is required. Analysis of circulating tumor cells (CTCs) can be used to evaluate pCR. We hypothesize that monitoring of thymidylate synthase (TYMS) and excision repair Cited by: 3. From the mathematical kinetic, and stochastic game theory to modelling mutations, onset, progression and immune competition of cancer cells N.

Bellomo and M. Delitala 1 Cited by: This review will outline a number of illustrative mathematical models describing the growth of avascular tumors. The aim of the review is to provide a relatively comprehensive list of existing models in this area and discuss several representative models in greater detail.

In the latter part of the review, some possible future avenues of mathematical modeling of avascular tumor development are Cited by:   Combinatorial drug therapy for cancer in the post-genomic era Cell or protein network dynamic and kinetic data measure the altered abundance, activity or cellular location of proteins over Cited by:   For this purpose, we combined a former cell kinetic model of erythropoiesis under chemotherapy and EPO applications developed by our group [10–13, 16] with a cell kinetic model of granulopoiesis under chemotherapy and G-CSF applications [3, 4, 12, 23].

These models were chosen for their clinically relevant applications and parameter settings Cited by: MiRp and miRp cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance In this article, we integrated bioinformatics, structural modelling, kinetic modelling, and experiments to find new avenues for overcoming chemotherapy resistance in aggressive tumour cells.

Computational Modelling of Cancer Development and Growth Bertuzzi A, Gandolfi A () Cell kinetics in a tumour cord. J Theor Biol – Bertuzzi A, Fasano A, Filidoro L, Gandolfi A, Sinisgalli C () Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence.

The aim of this report is to provide a mathematical model of the mechanism for making binary fate decisions about cell death or survival, during and after Photodynamic Therapy (PDT) treatment, and to supply the logical design for this decision mechanism as an application of rate distortion theory to the biochemical processing of information by the physical system of a cell.

Based on system Cited by: 2. Review of optimization methods for cancer chemotherapy treatment planning jcsb.

This book contains the optimisation methods for cancer chemotherapy. University. University of Calcutta. Course. Economics. Academic year. 16/ The fundamental strategy of chemotherapy is to maximize tumor eradication within the limits of tolerable toxicity to the organism.

To demonstrate the use of mathematical models in designing treatment protocols, we modeled the effect of chemotherapy on tumor mass and simulated the outcome of several neoadjuvant protocols for breast cancer by: Sein Buch»Cell Kinetic Modelling and the Chemotherapy of Cancer«erschien und wurde mit einem Preis der Internationalen Stiftung für den Ersatz von Tierversuchen ausgezeichnet.

Danach war er als Experte für mathematische Modelle in der Medizin am Bundesamt für Gesundheit in Bern und als freier Mitarbeiter an der Universität Bern tätig.

TY - JOUR AU - Clairambault, J. TI - Modelling Physiological and Pharmacological Control on Cell Proliferation to Optimise Cancer Treatments JO - Mathematical Modelling of Natural Phenomena DA - /6// PB - EDP Sciences VL - 4 IS - 3 SP - 12 EP - 67 AB - This review aims at presenting a synoptic, if not exhaustive, point of view on some of the problems encountered by biologists and Cited by: Calculate is a next-generation clinical calculator and decision support tool freely available to the medical community.

To date it contains + medical calculators in all manner of specialties. Kinetic eGFR (KeGFR) ECOG Score Assess quality of life and degree of well-being in patients with cancer Karnofsky Score / Performance Status. This paper presents a mathematical model for immune response against cancer aimed at reproducing emerging phenomena arising from the interactions between tumor and immune cells.

The model is stated in terms of integro-differential equations and describes the dynamics of tumor cells, characterized by heterogeneous antigenic expressions, antigen-presenting cells and by:. THE CHEMOTHERAPY DIET: 5 Steps to Staying Healthy During Cancer Treatment, Herbe - $ quick shipping top-notch support Hassle-Free Returns Home| Contact Us| About| FAQs| Add To Favorite Sellers Menu store categories Books Nonfiction Fiction & Literature Textbooks, Education & Reference DVDs & Movies DVDs & Blu-ray Discs VHS Tapes Wholesale Lots Music CDs Other Formats .Two major obstacles against successful chemotheraphy of cancer are (1) the cell-cycle-phase dependence of treatment, and (2) the emergence of resistance of cancer cells to cytotoxic agents.

One way to understand and overcome these two problems is to apply optimal control theory to mathematical models of cell cycle dynamics. CA model with distinguishing E & M cells (model B) It is now generally appreciated that EMT occurs during cancer cell progression and metastasis.

2,3 The EMT is a central process of embryogenesis Cited by: 4.

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